Deficiency of Endothelium-Specific Transcription Factor Sox17 Induces Intracranial Aneurysm
نویسندگان
چکیده
منابع مشابه
Deficiency of endothelium-specific transcription factor Sox17 induces intracranial aneurysm.
BACKGROUND Intracranial aneurysm (IA) is a common vascular disorder that frequently leads to fatal vascular rupture. Although various acquired risk factors associated with IA have been identified, the hereditary basis of IA remains poorly understood. As a result, genetically modified animals accurately modeling IA and related pathogenesis have been lacking, and subsequent drug development has b...
متن کاملDeficiency of Endothelial-Specific Transcription Factor Sox17 Induces Intracranial Aneurysm
re rea a a t t t t Abstract Background—Intracranial aneurysm (IA) is a common vascular disorder, which frequently leads
متن کاملDifferential Expression Pattern of the Human Endoderm-Specific Transcription Factor Sox17 in Various Tissues and Cells
BACKGROUND Sox17 is a member of the Sry-related high mobility group (HMG) of transcription factors that is necessary for endodermal formation and liver development in multiple species. Sox17 gene expression is required for formation of definitive endoderm that gives rise to various tissues. OBJECTIVE To examine the expression of Sox17 in various human tissues and cells. METHODS Semiquantita...
متن کاملSite-Specific Relationship Between Intracranial Aneurysm and Aortic Aneurysm.
BACKGROUND AND PURPOSE The high prevalence of intracranial aneurysms (IAs) in patients with a bicuspid aortic valve or coarctation of the aorta suggests a link between IA and aortic pathology. However, studies reporting this link do not sufficiently address the heterogeneity of IAs arising from different anatomic locations. This study aimed to explore whether a location-specific relationship ex...
متن کاملPatient- and Aneurysm-Specific Risk Factors for Intracranial Aneurysm Growth
21 頭蓋内動脈瘤増大に対する患者および動脈瘤に特異的な危険因子―系統的レビューとメタアナリシス Patientand Aneurysm-Specific Risk Factors for Intracranial Aneurysm GrowthA Systematic Review and Meta-Analysis Daan Backes, MD; Gabriel J.E. Rinkel, MD, FRCPE; Kamil G. Laban, MD, et al. Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus University Medical Center Utrecht, Utrecht, The Net...
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ژورنال
عنوان ژورنال: Circulation
سال: 2015
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.114.012568